Skin Booster Comparison — Rejuran vs. Juvelook vs. Lituo

A Practical Comparison of the Top 3 Skin Boosters in 2025

As the weather gets colder, many people begin to feel their skin becoming dry, dull, and rough. This is when skin boosters become one of the most effective treatments. A skin booster is essentially a “skin nutrient injection” that delivers active ingredients directly into the dermis—far deeper than what topical products can reach.

To help you choose the right option, this skin booster comparison outlines the strengths and differences of today’s most widely used treatments.

As of 2025, the three most in-demand boosters are:

• Rejuran (PN)

• Juvelook (PDLLA)

• Lituo (hADM)

If you're unsure which booster is best for your skin, this guide breaks down each option in the simplest, most helpful way.

Why Do They Last Different Amounts of Time?

Longevity varies depending on your skin condition, lifestyle, and treatment technique.

But in general:

• Rejuran / Juvelook → stimulate collagen production

• Lituo → directly replenishes collagen, elastin, and ECM components

Because of this structural difference, Lituo typically lasts the longest and delivers more immediate improvements.

Rejuran (PN): “Safest choice for hydration and gentle skin regeneration”

What It Does Well

• Extremely safe with minimal irritation

• Quickly improves hydration and skin texture

• Ideal for sensitive or thin skin

• Very natural-looking with no visible treatment signs

Limitations

• Shorter longevity (several weeks to ~2–3 months)

• Limited effect on elasticity or volume

Best For

• Sensitive, easily irritated skin

• People who want subtle, hydrated, smoother skin

• First-time booster patients

• Those who want results without looking “treated”

Juvelook (PDLLA): “A collagen stimulator that gradually improves pores, lines, and elasticity”

What It Does Well

• Boosts collagen production over time

• Improves pores, fine lines, elasticity

• Volume version can softly fill sunken areas

Limitations / Cautions

• Technique-sensitive (dilution, depth, and dose matter)

• Overuse or shallow injections may cause small nodules

• Results appear slowly and build naturally

Best For

• People who prefer slow, natural improvement

• Those wanting pore, fine-line, and elasticity benefits together

• Anyone who felt Rejuran’s longevity was too short

Lituo (hADM): “A next-generation booster that directly replenishes real skin components”

What It Does Well

• Made from acellular human dermal matrix (hADM) → highly biocompatible

• Immediate plumping & hydration + long-term collagen remodeling

• Very natural feel with low risk of nodules

• Improves hydration, texture, elasticity, and glow all at once

• Can be customized depending on clinic protocol

Limitations / Cautions

• Requires proper mixing and injection technique

• Higher price point

• Needle selection is key for smooth injection flow

Best For

• People who want the strongest overall skin improvement

• Those who want natural texture with long-lasting results

• Anyone who wants faster and more visible changes than PN/PDLLA

Suggested Treatment Intervals (General Guide)

• Rejuran: every 2–3 weeks × 3 sessions → maintenance every 2–3 months

• Juvelook (Skin): every 4 weeks × 2–3 sessions → touch-up every 6 months

• Juvelook (Volume): every 4–6 weeks × 2–3 sessions

• Lituo: every 4 weeks × 3 sessions → yearly maintenance

Common Aftercare & Precautions

• Mild swelling, redness, or bruising may occur briefly

• Avoid intense workouts, alcohol, or sauna for 3–7 days

• Pregnant/breastfeeding individuals need prior consultation

• Juvelook requires careful technique to avoid nodules

• Applying hydrating masks or ampoules after treatment boosts results

One-Sentence Summary

• Rejuran: Safest, hydrating, regenerative — best for short-cycle maintenance

• Juvelook: Collagen stimulator for gradual pore, texture, and elasticity improvement

• Lituo: Most powerful, longest-lasting option for overall skin quality enhancement